Oxygen-Inducible Glutamate Oxaloacetate Transaminase as Protective Switch Transforming Neurotoxic Glutamate to Metabolic Fuel During Acute Ischemic Stroke
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Effects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats
Excessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this en...
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Use of improvised explosive devices has significantly increased the incidence of traumatic brain injury (TBI) and associated neuropsychiatric deficits in the recent wars in Iraq and Afghanistan. Acute deleterious effects of single and repeated blast exposure can lead to long-term neurobiological effects and neuropsychiatric deficits. Using in vitro and in vivo shock tube models of blast-induced...
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Stroke is a leading cause of mortality and morbidity in developed countries and has increased incidence due to progression of average population age. Pharmalogical and mechanical reperfusion therapy, as primary therapeutic approaches, are only applicable to less than 10% of patients with a 50-70% efficacy. but about 90%of patients are severe restricted to these treatments. Glutamate excitotoxic...
متن کاملThe intracellular distribution, latency and electrophoretic mobility of L-glutamate-oxaloacetate transaminase from rat liver.
Richardson, E. M., Bulaschenko, H. & Dohan, F. C. (1958). J. clin. Endocrin. 18, 666. Richardson, E. M., Touchstone, J. C., Dohan, F. C., Bulaschenko, H., Landolt, I. & Applin, W. (1955). J. clin. Invest. 34, 285. Rimini, E. (1901). Gazz. chim. ital. 31, II, 84. Romani, J. D. (1956a). C.R. Soc. Biol., Paris, 150, 644. Romani, J. D. (1956b). C.R. Soc. Biol., Paris, 150, 887. Romani, J. D. & Able...
متن کاملDetermination of the Chromosomal Location of a Glutamate Oxaloacetate Transaminase Structural Gene Using Triticum-agropyron Translocations1
The glutamate oxaloacetate transaminase (GOT) zymogram phenotypes of a series of 15 translocation lines, a chromosome addition line and a chromosome substitution line were determined. In each of the translocation lines a segment of the long arm of Triticum aestivum chromosome 3D has been replaced by a portion of an Agropyron elongatum homoeologue. Evidence was obtained that the products of the ...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2011
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2011.3930